Chest wall, or musculoskeletal chest pain, is a common cause of chest pain and can be produced by several different medical conditions. Oct 5, - Pleurisy. This condition results when the membrane that surrounds the lungs and lines the inside of the chest cavity becomes irritated and inflamed. Common causes include a viral infection, such as the flu, or a bacterial infection, such as bacterial pneumonia. When the left lung is affected, left-side pain will result Heart and chest · Digestive issues · Other causes.